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2019, 09, v.12 727-732
转化生长因子β信号在骨关节炎中的作用
基金项目(Foundation): 国家自然科学基金面上项目(81572218);; 上海市自然科学基金(13ZR1439100);; 上海市卫生局局级课题面上项目科研基金(20124303)
邮箱(Email): drzhanglizhi001@163.com;
DOI:
摘要:

骨关节炎(OA)是整个关节的退变性疾病,不仅有关节软骨退变,还有软骨下骨和关节周围组织的病变。研究显示,转化生长因子β(TGF-β)参与了早期关节的形成,对骨、软骨的发育和关节重塑起着重要作用,是维持关节稳态的关键因子之一。近年的研究还显示,TGF-β参与了软骨、软骨下骨的退变和滑膜的炎症,是关节破坏的重要因素。本文对TGF-β信号在OA发生和发展中的作用进行综述,以期为OA的研究和治疗探寻新方法和思路。

Abstract:

Osteoarthritis(OA) is a degenerative disease of the whole joint. It is not only involved in the articular cartilage, but also in the subchondral bone and periarticular tissues. Studies have shown that transforming growth factor β(TGF-β) is involved in joint formation, plays an important role in bone and cartilage development and joint remodeling, and is one of the key factors to maintain joint homeostasis. However, recent studies have shown that TGF-β participates in the degeneration of cartilage and subchondral bone and synovial inflammation, and is an important factor in joint destruction. In this article, we reviewed the role of TGF-β signal in the occurrence and development of OA in order to explore new methods and ideas for the research and treatment of OA.

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基本信息:

中图分类号:R684.3

引用信息:

[1]张立智,卫禛,张世民.转化生长因子β信号在骨关节炎中的作用[J].中华骨与关节外科杂志,2019,12(09):727-732.

基金信息:

国家自然科学基金面上项目(81572218);; 上海市自然科学基金(13ZR1439100);; 上海市卫生局局级课题面上项目科研基金(20124303)

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